Anti-TSH receptor antibodies (TRAb)

The thyrotropin receptor antibody (TRAb) test measures antibodies against thyroid-stimulating hormone (TSH) receptors. This test is performed to confirm the diagnosis of Graves' disease, forecast its progression, and aid in treatment planning. In pregnant women, TRAb testing is conducted at the beginning and end of pregnancy to assess the risk of developing hypo- or hyperthyroidism in the fetus and newborn.

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Test description

The TSH receptor antibody (TRAb) test measures the level of antibodies against TSH receptors. It is performed to confirm the diagnosis of Graves' disease, to predict its progression, and to assist in treatment planning. In pregnant women, TRAb testing is done at the beginning and end of pregnancy to assess the risk of hypo- or hyperthyroidism in the fetus and newborn.

When to Perform the Test?

This test is conducted to detect specific autoantibodies (Ab) against thyroid-stimulating hormone receptors (TSH-R) present on the thyroid surface. These antibodies stimulate the receptors, leading to an overproduction of thyroid hormones. Consequently, hyperthyroidism develops, and the gland may become damaged.

Diseases

TSH receptor antibodies (TRAb) are measured when diagnosing conditions such as Graves' disease.

Symptoms

The TRAb test is conducted after observing symptoms such as thyroid eye disease (exophthalmos), unexplained weight loss, excessive sweating with heat intolerance, brittle nails, thin and oily hair, insomnia, weakness and difficulty concentrating, irritability, diarrhea, menstrual irregularities, and tachycardia.