Antibodies against intrinsic factor of Castle (Anti-IF)

The test for antibodies against Castle's intrinsic factor (Anti-IF) helps detect autoantibodies that can lead to vitamin B12 deficiency and pernicious anemia (Addison-Biermer disease). The presence of these antibodies may indicate issues with vitamin B12 absorption.

When to perform the test?

The test is performed for diagnosing Addison-Biermer anemia or pernicious anemia in patients with diagnosed endocrine diseases, such as Graves-Basedow disease, Type 1 diabetes, or Crohn's disease, which can be associated with this type of anemia.

Conditions:

Antibodies against Castle's intrinsic factor (Anti-IF) are measured in the diagnosis of Addison-Biermer anemia or pernicious anemia.

Symptoms:

The Anti-IF antibody test is conducted when symptoms such as weakness, fatigue, rapid heartbeat (tachycardia) and/or chest pain, upset stomach, nausea, vomiting, heartburn, loss of appetite, weight loss, headaches, pale skin, peripheral neuropathy (numbness in hands and feet), depression, confusion, and memory problems are observed.