Breast and ovarian cancer (BRCA1 and BRCA2) - home collection kit

Breast and ovarian cancer

One way to prevent breast and ovarian cancer is to perform tests to determine or rule out the presence of selected mutations  of the BRCA 1 and BRCA2 genes that characterize the population. Genetic testing assesses whether a person has the most common for a given population, selected mutations within the genes tested that may  be responsible for an increased risk of disease. Currently, it is one of the best ways to prevent ovarian cancer.


A patient with this information can implement tailored prevention and an individually tailored screening calendar.

Testing of BRCA1 and BRCA2 gene mutations - genetic material is isolated from a saliva sample provided by the patient, which is then subjected to laboratory testing. The 8 most common genetic mutations within the BRCA1 and BRCA2 genes in the Polish population  are examined BRCA1 - 6 mutations named: (c.181T>G / p.(Cys61Gly), c.68_69delAG / p.(Glu23Valfs*17) (185delAG), c.2563C>T / p.(Gln855*) (Gln855Ter), c.3700_3704delGTAAA / p.(Val1234Glnfs*8) (3819del5), c.4034delA / p.(Glu1346Lysfs*20) (4153delA) and c.5266dupC / p.(Gln1756Profs*74) (5382insC)) BRCA2 - 2 mutations: (c.7757G>A / p.(Trp2586*) (7985G>A), c.9371A>T / p.(Asn3124Ile) (9599A>T)). Self-sampling kit - includes the necessary documentation, accessories for taking and securing the sample, and instructions. Free delivery of the pledge and collection of collected samples, sending the test result by mail.

Your benefits

Ensure that you are not burdened with one of the 8 most common mutations within the BRCA1 and BRCA2 genes in Poland. In the event of a result indicating a mutation, you will be able to take appropriate action earlier to reduce the risk of developing cancer, leading to early diagnosis and allowing for prompt and appropriate treatment. The risk of developing cancer will be reduced, leading to early diagnosis and allowing for prompt and appropriate treatment.

No need to donate blood

You do not need to donate blood for the test. You will take the saliva sample yourself - thanks to the instructions included in the box with the kit, it is very easy.

You will save the time required for a visit to a medical facility and a doctor's appointment where the doctor will issue a referral. The test can be performed "at the patient's request", without the need to provide a doctor's referral. The test can be performed "at the patient's request" without the need to provide a doctor's referral You take the test once, and the result is valid for life and is a valuable source of information about your health.

Delivery and receipt of the sample, like sending the result, is free. You will receive the saliva self-sampling kit, sent by courier, within 5 business days.

Breast and Ovarian Cancer - Shopping Process

1. To purchase the review, select the "courier shipping" option in both fields.
2. Add the product to your shopping cart.
3. Select the product
4. Select a form of payment.
5. Fill in your personal information.
6. Pay your order.

Realization

The sample kit box will be delivered to you via courier. When adding the product to your cart, in the "all outlets" box, select "Courier shipping". Then add the product to your cart. Pay for the purchase, fill out the contact form, including shipping details. A package containing the sample kit and instructions, addressed envelope and documents will be delivered to the specified address within 5 business days.

After taking the sample according to the instructions and completing the documents, pack the material and the required documentation into the addressed envelope. Pack the envelope Send the envelope to the address on the side of the envelope. You do not need to pay for the postage, it is prepaid. The result of the study can be received electronically. Waiting time 15 days.

Order a home study and get it done at your convenience 

Purpose of the test and information about cancer

The aim of the study is to identify genetic mutation that may contribute to the occurrence of a specific disease. However, the absence of any genetic mutation identifiable in the test does not mean that the disease will never develop.

Genetic ovarian and breast cancer are caused by BRCA1 and BRCA2 gene mutations. The gene mutation test provides information about the risk of developing breast and ovarian cancer. . The risk of developing breast cancer in carriers of mutant BRCA genes increases to 80% and for ovarian cancer to 40%.

The factors that increase the risk of cancer are: excessive body weight, unhealthy diet, insufficient physical activity, smoking cigarettes and others.

Every genetic test has its limitations, so it is possible that the genetic mutation responsible for the disease exists in a different gene than the tested gene.

Breast cancer

• The most common cancer in women in Poland.
• Every year about 17 thousand Polish women develop breast cancer.
• The particularly exposed group includes women whose lifestyle increases the risk of cancer and those whose mother, grandmother, daughter, aunt or sister suffered from this type of cancer.
• Early detected cancer can be effectively treated to recovery, while at advanced stages it requires invasive therapy including breast removal - mastectomy.

Ovarian cancer

• It can develop undetected or gives uncharacteristic symptoms, which might be confusing in examination and makes the early diagnosis difficult.
• It is often an inherited genetic condition, and if a woman is a carrier of the mutation, the risk of the disease increases significantly.
• If ovarian cancer is detected at an advanced stage, the chances of complete recovery are low and the prognosis unfavourable.

Results and interpretation

The interpretation of a genetic test result depends on current medical knowledge as well as a number of environmental and family factors.

Incomplete medical information about a patient or family, including any relationship other than the declared relationship between members of the family, may lead to misinterpretation of the results. Therefore, the test result should be consulted with a physician.

A correct test result does not exclude the occurrence of a less common BRCA1/2 gene mutation.

Genetic analysis is performed on the basis of a cheek swab. The results depend primarily on the quality and quantity of DNA in the collected material.

NOTE: The result of the test is delivered directly to the address indicated by the Patient. It is not consulted by medical personnel in Medicover Centres and does not include medical interpretation. In case of a result indicating an increased risk of cancer development, a gynaecologist or an oncologist should be consulted.

Procedure

Strictly follow the sample collection rules and the instructions included in the unassisted collection kit. The patient collects sample material for genetic testing. Irrespective of strict compliance with all laboratory standards, the isolated material may not be in sufficient quantity or may be degraded (destroyed), which makes it unusable for the genetic analysis requested. In such a case, the material will have to be collected again (swab from the mucous membrane on the inside of the cheek).

Further medical decisions regarding the planned therapy or disease prevention methods should be based on a comprehensive assessment of the patient's condition and the genetic test results should be complemented with thorough examination supporting the decision about the treatment.