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Methotrexate

Testing of serum methotrexate levels is performed during the monitoring of treatment.

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  • Test description
Test description

Methotrexate - a folic acid antagonist, a drug Anticancer and immunosuppressant. Mechanism of action involves inhibition of the synthesis of purine nucleotides and thymidines, which are essential for DNA synthesis and repair and cellular replication cell replication.The indication for the use of methotrexate is acute lymphoblastic leukemia in children, acute lymphoblastic and myeloid leukemia in adults, cancer of the breast, ovary, testes, head, bone and many others. Testing the serum concentration of this drug is performed during treatment monitoring. A folic acid analogue - folinate calcium is a substance administered to a patient who has been exceeded the recommended concentration of methotrexate.