Prenatal testDNA 3

What is the test about?

Prenatal testDNA 3 is a non-invasive prenatal test with high sensitivity of over 99%. It provides important information about the child's health. The test requires only a small blood sample from the mother. It contains fetal DNA, which the laboratory analyzes using precise methods. This is why Prenatal testDNA 3 is both safe and effective.

When should the test be done?

Prenatal testDNA 3 can be done after the 10th week of pregnancy.

It can be performed by almost any mother who wants to check the health of her unborn child.

It is especially recommended for:

• mothers over 35 years old due to the increased risk of genetic diseases in the child. Thanks to the test's high effectiveness, a correct result can bring peace of mind;
• when PAPP-A and combined tests show elevated risk of trisomies in first trimester prenatal tests. A correct result can help avoid amniocentesis.

The test is also recommended if there were genetic diseases in the previous pregnancy or in the family, or if there are contraindications for invasive tests.

The test can be performed in both single and twin pregnancies.

What does Prenatal testDNA 3 test for?

Prenatal testDNA 3 tests for the most common trisomies: trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and gender on request.

What are the abnormalities tested by Prenatal testDNA 3?

• TRISOMY 21: caused by an extra copy of chromosome 21 (Down syndrome). It is the most common genetic cause of intellectual disability and is estimated to occur in 1/700 births, although the risk of conceiving a child with trisomy 21 is closely related to the mother's age.
• TRISOMY 18: caused by an extra copy of chromosome 18 (Edwards syndrome). It is associated with a high risk of miscarriage and causes severe intellectual disability. Newborns with trisomy 18 often have congenital heart defects and other pathological conditions that shorten their expected lifespan. It is estimated that trisomy 18 occurs in 1/5000 births, although the risk of conceiving a child with trisomy 18 is closely related to the mother's age at conception.
• TRISOMY 13: caused by an extra copy of chromosome 13 (Patau syndrome). It is associated with a high risk of miscarriage. Newborns with trisomy 13 may have heart defects and other pathological conditions, making survival beyond the first year of life rare. It is estimated that trisomy 13 occurs in 1/16,000 births, although the risk of conceiving a child with trisomy 13 is closely related to the mother's age at conception.

Why is it worth doing?

The Prenatal testDNA 3 provides important information about the child's health before birth. A correct result can bring peace of mind and help avoid invasive tests, such as amniocentesis.

• EFFECTIVE – high sensitivity has been confirmed in a large clinical validation study with over 70,000 pregnancies. Sensitivity for trisomies 21, 13, and 18 is over 99%.
• RELIABLE – the laboratory has extensive experience in non-invasive prenatal testing and has conducted over 300,000 NIPTs.
• SAFE AND SIMPLE – only a small blood sample from the mother is required, which can be collected at home with online results.
• CLOSE TO YOU – you can take the test at one of 300 collection points or conveniently at home.

Prenatal testDNA is performed using CE-IVD certified software, equipment, and reagents in an accredited UNI EN ISO 15189:2013 laboratory, number 0018M.

What makes it stand out among other NIPTs?

• Confirmed high effectiveness. Prenatal testDNA's high effectiveness has been confirmed in extensive validation with over 70,000 pregnancies. The validation was conducted at a single center, which allows for a better assessment of the test's effectiveness than when data is sourced from various locations. Furthermore, it was conducted under the same conditions in which our patients' samples are usually analyzed.
• No need to stop heparin before the test. Unlike some other prenatal tests, Prenatal testDNA does not require stopping heparin before the sample is taken. This means you do not need to worry about adjusting your dosage.
• Fast online results. You will receive your result in the secure Patient Panel within 4-8 days (working days, counted from the time the sample arrives at the laboratory).

What does the test price include?

The price of the test includes:

• Analysis for genetic abnormalities and gender (on request) according to the selected package, with online results in the secure Patient Panel.
• Sample collection at one of 300 collection points or at home (nurse visit) throughout Poland.
• Consultation with a clinical geneticist if the test detects abnormalities (positive result). The doctor will explain the meaning of the result and recommend further actions.
• Guidelines on "How to read the result" developed in cooperation with a clinical geneticist. These make interpreting the result easier.

The time for test implementation from the purchase is 3 weeks.

Preparation for the test

• No fasting required, you can eat a meal.
• You can take heparin, there is no need to stop the medication or change its dosage.
• We recommend drinking fluids the day before and on the day of sample collection to stay hydrated.
• Review the list of contraindications in the last tab. If you have any doubts, please contact us.

Test step by step

1. After purchasing the test, our medical consultant will contact you to schedule the appointment at a location near you (you can choose one of 300 facilities across Poland or opt for a home visit with a nurse).
2. On the scheduled date, visit the chosen facility or wait for the nurse's home visit.
3. During the visit, a test order form will be signed. We will send the form via email beforehand for your review.
4. For the test, a blood sample is taken from the mother's cubital vein, similar to a blood test for a complete blood count. The sample collection is quick, and the entire visit at the facility or home visit usually takes up to 20 minutes.
5. The sample, along with the order form, is sent to the Eurofins Genoma laboratory in Italy, where the analysis is performed. The sample transport is quick and takes only 1-2 working days, similar to the delivery of samples to laboratories in Poland. The transport is secure, using a special DHL Medical Express shipment at room temperature (samples are not stored in the refrigerator).
6. The test result is available for download online in the secure Patient Panel. This is the original document – it is electronically signed.
7. The waiting time for the result is 4-8 working days from the time the sample is delivered to the laboratory.
8. If an abnormal result is obtained, you can schedule a consultation with a clinical geneticist at no additional cost. During the phone consultation, the doctor will explain the result and recommend further steps.

Prenatal testDNA 3 is non-invasive and can be performed by almost any pregnant woman. However, there are contraindications for the test.

The test cannot be performed in the following cases:

• Pregnancy with 3 or more fetuses.
• Pregnancy under 10 weeks.
• Vanishing twin if development cessation occurred after the 8th week of pregnancy or less than 8 weeks have passed from the cessation to the sample collection.
• Presence of tumor DNA in the mother's blood.
• Monochorionic twin pregnancy.

In some situations, it is recommended to wait a certain period before collecting the sample:

• It is recommended to wait 4 weeks after the last immunotherapy.
• It is recommended to wait 4 weeks after the last treatment with human plasma albumin.
• It is recommended to wait 12 months after a blood transfusion.

Organ transplant and abnormal karyotype (inversions, translocations, deletions, duplications, mosaicism) require consultation before performing the test. It is not recommended to perform the test after stem cell therapy.