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Clostridium difficile
Gram-positive bacteria, some toxic strains produce dangerous toxins A and B, which can directly damage intestinal cells.
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The action of toxins on the body causes severe diarrhea and colitis. Infection with the bacteria often occurs after hospitalization, surgery, chemotherapy, prolonged antibiotic therapy, or proton pump inhibitor treatment. The most severe form of bacteremia is pseudomembranous colitis, which can be fatal.