Blood clotting factor II
Coagulation factor II, protrombin is a proenzyme activated by thrombokinase to thrombin during blood clotting which allows fibrinogen to be converted to fibrin

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Coagulation factor II
Clinical significance
Coagulation factor II (prothrombin) is synthesized in the liver as a vitamin K-dependent protein. Active factor X converts prothrombin to thrombin. Congenital prothrombin deficiency manifests itself mainly with bleeding from the mucous membranes of the mouth, nose, genital and urinary dróg and following trauma. Rarely, delivery hemorrhages occur.
Patient preparation
Material: Citrate plasma