Endometriosis test - package

The innovative, minimally invasive Endometriosis test, invented by Polish scientists. The test reduce the time of a correct diagnosis.

Endometriosis is a non-obvious disease, and it often takes several years to make a correct diagnosis. This time is significantly shortened by a novelty on the diagnostic testing market - the minimally invasive Endometriosis EndoRNA qRT-PCR test

The EndoRNA test consists in the determination of the expression level of the gene encoding the fucosyltransferase 4 (FUT4) protein. Latest research has shown that FUT4 (mRNA) expression is significantly increased in the endometrial cells of patients with endometriosis compared to the endometrium of healthy patients. This allows to confirm the disease in patients with suspected endometriosis or to rule out this disease.

The Diagendo endoRNA test has a very high sensitivity and specificity (95%), which confirms the reliability of the results.

Endometriosis is an insidious disease that affects 2 million women in Poland.

The most common symptoms of endometriosis include:

·       excessive menstrual periods and pain during bleeding,

·       sharp, wrenching pain occurring with changes in the menstrual cycle in different areas of the abdomen,

·       dyspareunia (painful intercourses),

·       pain during physiological activities, e.g. when urinating or defecating.

In addition to pain, patients suffering from endometriosis may complain of:

·       diarrhoea and constipation (often occurring or exacerbated during a particular phase of the cycle),

·       recurring flatulence,

·       polyuria,

·       intermenstrual bleeding and spotting.

An important symptom of endometriosis is difficulty getting pregnant. It is estimated that approximately 30% of infertile patients are affected.

The test is performed quickly and safely in an outpatient setting. The examination involves collecting a smear from the uterine cavity. The collection takes a few minutes, is minimally invasive.

The collected material is transferred to the diagnostic laboratory, where the test is performed using a PCR reaction.

The waiting time for the results is 10-14 working days.

Performance of the Test at Invimed Clinic

The package includes:

1. Qualification meeting for the test
2. Execution of the test
3. Gynecologist consultation after receiving the results

Test results and additional information The timing of the test is crucial for the medical quality of the sample obtained – it should be taken after ovulation, preferably between the 14th and 20th day of the menstrual cycle.

The waiting time for the results is 14 days.

Qualification visit

Before undergoing the examination, patients are required to attend a qualification visit (on any day of the menstrual cycle) at one of the InviMed clinics. The patient should bring a current (performed within the last 12 months) cytological examination result for qualification.

HOW TO PURCHASE THE EXAMINATION?

1. Choose the city and indicate the clinic where you want to undergo the examination.
2. Add the examination to the cart and pay for the order.
3. You will receive a purchase confirmation to the email address provided in the order.
4. Our consultants will contact you to confirm the date of the qualification visit.
5. If you wish to contact our consultants, please call the number 500 900 888.
6. For the clinic visit, please bring a document confirming your identity (ID card/passport if you are not a Polish citizen).

After the purchase, you have 3 months to undergo the examination.

NOTE! After purchasing the test, please contact the Hospital Hotline Team (500 900 900) to book the appointment.

Performing the test:

The test is performed by a gynaecologist during an outpatient visit. The specimen for testing is collected by aspiration biopsy. Preparation and the procedure itself takes a few minutes. Afterwards, the patient can return to normal daily activities.

The time of collection is very important for the medical quality of the test - it should be collected after ovulation, preferably between the 17th and the 27th day of the menstrual cycle.

The specimen cannot be taken from a pregnant woman. The test will not be performed during the pre-ovulation period.

Results interpretations

Results are available in 10 days. The results are provided by the doctor.

A positive result of the EndoRNA test indicates an increased expression of the FUT4 gene, which correlates with a high probability of endometriosis.

A negative result of the EndoRNA test indicates low expression of the FUT4 gene, which excludes endometriosis.

Ambiguous EndoRNA result - relative expression of the FUT4 gene does not allow for unambiguous classification of the result as positive or negative. In the group of patients who obtained an ambiguous result, clinical data should be additionally analysed in conjunction with the test results and additional diagnostic procedures should be performed depending on the situation. In the absence of symptoms, it is recommended to repeat the test after 12 months.