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Alpha-1-antitrypsin
Alpha-1 antitrypsin is a protein substance produced by liver cells and immune system cells that inhibits the activity of protein-digesting enzymes. It belongs to the acute-phase proteins, meaning its concentration increases rapidly during inflammation.
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In an ideal state of balance, its presence is not detected in the digestive tract. The determination of α-1 antitrypsin in stool is used in detecting protein-losing enteropathy, which accompanies non-specific inflammatory bowel diseases, as it is not digested by intestinal enzymes. A correlation has also been shown between the concentration of α-1 antitrypsin in stool and the frequency of cow's milk protein allergies. Elevated results appear in cases of intestinal protein loss and inflammatory changes in the intestinal mucosa.