Coagulation factor VII

Coagulation factor VII

Clinical significance

Coagulation factor VII (proconvertin) is a vitamin K-dependent protein. It is produced in the liver and macrophages. Factor VII deficiency occurs with a frequency of 1/500,000 of the general population. Most patientsów with low factor VII activity experience postoperative bleeding, a tendency to bruise, nosebleeds, and in women, bleeding from the dróg of the genitals, including postpartum hemorrhages. Causes of decreased factor VII activity: congenital deficiencyór, treatment with vitamin K antagonists, vitamin K deficiencyór, liver damage, acquired FVIII inhibitor (cancer and autoimmune diseases). Causes of increased activity: fresh myocardial infarction or stroke mózgu, diabetes mellitus, hypertriglyceridemia, administration of vitamin K. Increased factor VII activity is associated with an increased risk of coronary incidents.

Patient Preparation

Material: Plasma